MEDICAL

T2, a chloroform/methanol extract of the herb Tripterygium wilfordii Hook f, has been used in China for the treatment of autoimmune and inflammatory diseases for many years. Recent experimental evidence has confirmed that T2 has potent anti-inflammatory and immunosuppressive activity, and a United States Food and Drug Administration-approved clinical trial is currently exploring the efficacy of T2 in the treatment of rheumatoid arthritis. Despite the potential therapeutic benefits of T2, there is ample documentation that T2 is toxic, targeting, among other things, the hematopoietic system, and its use has resulted in cases of leukopenia, thrombocytopenia, and aplastic anemia. This investigation was undertaken to characterize the in vitro effects of T2 on primary human CD34-positive (CD341) bone marrow cells. Our results demonstrate that T2 has a potent inhibitory effect on the clonogenic response of human bone marrow cells to exogenously added hematopoietic growth factors. The inhibition of colony formation by T2 is not the result of direct cytotoxicity or increased apoptosis and indicates a functional suppression of hematopoiesis. Additional experiments demonstrate that T2 also alters transcriptional regulation in bone marrow cells by inhibiting nuclear factor-kB. This transcription factor is found in CD341 bone marrow cells and has been recently shown to be a requirement for colony formation. These results demonstrate that therapeutic concentrations of T2 exert a significant hematotoxic effect by inhibiting growth factor response in CD341 bone marrow cells and suggest that inhibition of nuclear factor-kB may play a role in the blood dyscrasias encountered with the use of this drug.

(Read More on Free Ebook at PDF Format)

Download Hematotoxicity of the Chinese Herbal Medicine Tripterygium wilfordii Hook f in CD34-Positive Human Bone Marrow Cells.pdf

Advertisement:

Tags: Chinese Herbal Medicine | inflammatory diseases | Positive Human Bone Marrow Cells

You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

DO YOU WANT PUBLISH THIS ARTICLE INTO YOUR SITE?

<h2>Hematotoxicity of the Chinese Herbal Medicine Tripterygium wilfordii Hook f in CD34-Positive Human Bone Marrow Cells</h2> <p style="text-align: justify;">T2, a chloroform/methanol extract of the herb Tripterygium wilfordii Hook f, has been used in China for the <a title="treatment" href="http://911medicalcare.com/medicalcare/treatment/">treatment</a> of autoimmune and inflammatory diseases for many years. Recent experimental evidence has confirmed that T2 has potent anti-inflammatory and immunosuppressive activity, and a United States Food and Drug Administration-approved clinical trial is currently exploring the efficacy of T2 in the treatment of rheumatoid arthritis. Despite the potential <a title="therapeutic" href="http://911medicalcare.com/medicalcare/therapeutic/">therapeutic</a> benefits of T2, there is ample documentation that T2 is toxic, targeting, among other things, the hematopoietic system, and its use has resulted in cases of leukopenia, thrombocytopenia, and aplastic anemia. This investigation was undertaken to characterize the in vitro effects of T2 on primary human CD34-positive (CD341) bone marrow cells. Our results demonstrate that T2 has a potent inhibitory effect on the clonogenic response of human bone marrow cells to exogenously added hematopoietic growth factors. The inhibition of colony formation by T2 is not the result of direct cytotoxicity or increased apoptosis and indicates a functional suppression of hematopoiesis. Additional experiments demonstrate that T2 also alters transcriptional regulation in bone marrow cells by inhibiting nuclear factor-kB. This transcription factor is found in CD341 bone marrow cells and has been recently shown to be a requirement for colony formation. These results demonstrate that therapeutic concentrations of T2 exert a significant hematotoxic effect by inhibiting growth factor response in CD341 bone marrow cells and suggest that inhibition of nuclear factor-kB may play a role in the blood dyscrasias encountered with the use of this drug.</p> <p style="text-align: justify;">(Read More on Free Ebook at PDF Format)</p> <p style="text-align: justify;"><a href="http://911medicalcare.com/pdf/hematotoxicity-of-the-chinese-herbal-medicine-tripterygium-wilfordii-hook-f-in-cd34-positive-human-bone-marrow-cells" target="_blank">Download</a> Hematotoxicity of the Chinese Herbal <a title="Medicine" href="http://911medicalcare.com/healthcare/medicine/">Medicine</a> Tripterygium wilfordii Hook f in CD34-Positive Human Bone Marrow Cells.pdf</p><br/><a href="http://www.socialmarker.com/?link=http://911medicalcare.com/medicine/hematotoxicity-of-the-chinese-herbal-medicine-tripterygium-wilfordii-hook-f-in-cd34-positive-human-bone-marrow-cells/&title=Hematotoxicity+of+the+Chinese+Herbal+Medicine+Tripterygium+wilfordii+Hook+f+in+CD34-Positive+Human+Bone+Marrow+Cells&text=...&tags=" target="_blank"><img src= "http://www.socialmarker.com/bookmark.gif" border="0" /></a><noscript><a href="http://www.socialmarker.com" >Social Bookmarking</a></noscript> <p>The article <a href="http://911medicalcare.com/medicine/hematotoxicity-of-the-chinese-herbal-medicine-tripterygium-wilfordii-hook-f-in-cd34-positive-human-bone-marrow-cells/">Hematotoxicity of the Chinese Herbal Medicine Tripterygium wilfordii Hook f in CD34-Positive Human Bone Marrow Cells</a> is provided by <a href="http://911medicalcare.com" title="Manual Nurse and health Guidelines"> Manual Nurse and Health Guidelines</a>. The article from<a href="http://911medicalcare.com" title="Medical"> Medical</a> site is freely distributed for non-commercial purposes to include the source for the article and does not alter the content.</p>

*copy-paste the code above into your post blog

Recent searches: sample letter of recommendation for nurse Nurses application letter hospital nurse application letter hospital nurse sample cover letter for RN New graduate sample letter of recommendation for nurse sample letter of recommendation for Physical thera sample cover letter for RN New graduate Pathophysiology of Diabetes Mellitus Phlebotomist