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Acute Myeloid Leukemia, Myelodysplastic Syndromes and Mesothelioma

October 29th, 2009 by admin | Filed under Mesothelioma


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Cytologically or histologically confirmed diagnosis of 1 of the following:

Acute myeloid leukemia, meeting the following criteria:
• Documented Wilms tumor-1 (WT-1)-positive disease demonstrated by WT-1 protein on a pretreatment bone marrow biopsy OR detectable disease with real-time quantitative reverse transcriptase-polymerase chain reaction (RQ-PCR)
• Completed induction chemotherapy, achieved clinical remission, and completed postremission therapy OR achieved clinical remission and have no plans for further postremission chemotherap y (? 65 years of age)

Myelodysplastic syndromes, meeting the following criteria:

• Documented WT-1-positive disease demonstrated by WT-1 protein on a pretreatment bone marrow biopsy OR detectable disease by RQ-PCR
• International Prognostic Scoring System (IPSS) score of ? Int-2
• Not a candidate for cytotoxic chemotherapy

Non-small cell lung cancer, meeting the following criteria:
• Positive tumor staining for WT-1 in > 10% of cells
• Stage III or IV disease
• Completed chemotherapy, surgery, and/or radiotherapy

Mesothelioma, meeting the following criteria:

• Positive tumor staining for WT-1 in > 10% of cells
• Unresectable or relapsed disease
• Chemo-naive or received 1 prior chemotherapy regimen
• Malignant pleural mesothelioma or peritoneal mesothelioma

(Read More on Free Ebook at PDF Format)

Download Acute Myeloid Leukemia, Myelodysplastic Syndromes and Mesothelioma.pdf




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