Vaccines made from peptides may help the body build an effective immune response to kill cancer cells. Biological therapies, such as GM-CSF, may stimulate the immune system in different ways and stop cancer cells from growing. Giving vaccine therapy together with GM-CSF may kill more cancer cells.
Cytologically or histologically confirmed diagnosis of 1 of the [...]

Surgical resection with regional chemotherapy for selected patients with MM is associated with durable PFS,OS, and improved QOL
Factors associated with favorable outcome are: age <60 yrs, favorable tumor biology, and completeness of tumor resection
Molecular profiles of MPM are associated with distinct biological behaviors
The molecular characteristics of peritoneal mesothelioma have identified potential new targets for therapy
Cancer [...]

Malignant pleural mesothelioma (MPM) is a rare tumor generally associated with asbestos exposure. The annual incidence of malignant mesothelioma in the United States is approximately 3000 cases per year, of which approximately 85% are pleural mesotheliomas. Mesothelioma most commonly develops in the fifth to seventh decade. The incidence appears to be increasing, due to the [...]

Malignant mesothelioma arises from the cells lining the pleural and peritoneal cavities, and is usually associated with previous exposure to asbestos or previous chest irradiation (1, 2). Currently, the incidence of malignant mesothelioma appears to be rising, probably reflecting the long latency between the widespread exposure to asbestos-containing materials in previous decades and the clinical [...]

Malignant mesothelioma in the western world is often associated with asbestos exposure. It is a relatively rare cancer that causes f2,500 deaths yearly in the United States and 1,000 deaths yearly in the United Kingdom. In contrast, among people born in the Cappadocian (Turkey) villages of Tuzkoy, Karain, and ‘‘Old’’ Sarihidir, f50% of deaths are [...]

Mesothelioma: an insidious, aggressive tumor arising from mesothelial surfaces (tissues that line body cavities).
Occupational exposure to asbestos
Primary: mining of asbestos
Secondary: carpentry, brake linings, boilers, plumbers, defense industry.
How asbestos affects the pleura
Fibers irritate the pleura by penetrating tissue and causing scarring.
Fibers cause breakage of mitotic spindles, disrupting mitosis, and causing chromosomal damage.
Induces DNA damage
Phosphorylation of MAP [...]

Despite many reports on the use of chemotherapy in the palliative treatment of malignant pleural mesothelioma, only a limited amount of high-quality evidence exists on which to base recommendations.
One large randomized trial comparing chemotherapy with pemetrexed 500 mg/m2 and cisplatin 75 mg/m2 every three weeks to cisplatin alone demonstrated improved survival and quality of life [...]

To make provision corresponding to provision in Great Britain to break the occupational link and extend payment of compensation to all people suffering from diffuse mesothelioma. To do this the Department proposes to introduce a new scheme and to provide for the recovery of lump sum payments (including extrastatutory payments) paid pursuant to the Pneumoconiosis, [...]

The Mesothelioma Applied Research Foundation is the national non profit collaboration of researchers, physicians, advocates, patients and families dedicated to eradicating mesothelioma (meso) as a life-ending disease. We believe meso can be cured. We believe the resources to support the necessary medical research are available, especially given the human toll of suffering the disease causes, [...]

Malignant penitoneal mesothelioma is a rare neoplasm which arises from the penitoneal lining of the abdomen. It usually occurs in middle-aged men and is thought related to asbestos exposure. In a series of 392 mesotheliomas collected from single sources, 65% were primary to the pleura, 33% primary to the penitoneum, and 2% primary to both [...]